A trial of smoking cessation, risk factor modification, diet and exercise, as well as pharmacologic treatment should be attempted before any procedures. When indicated, the type of intervention (surgery or angioplasty) depends on several factors. Intermittent claudication can vary due to several factors. The lifetime incidence of amputation in a patient with claudication is less than 5% with appropriate risk factor modification. Procedures for claudication are usually not limb-saving, but, rather, lifestyle-improving. However, interventions are not without risks, including worsening the patient’s perfusion, and should be reserved until a trial of conservative management has been attempted. Many people will actually realize an increase in their walking distance and pain threshold with exercise therapy. In cases in which the claudication limits a person’s ability to carry out normal daily functions, it is appropriate to intervene. Depending on the characteristics of the occlusive process, and patient comorbidities, the best option for treatment may be either surgical or endovascular.