Rationale and Comments

Amenorrhea is the absence of menstruation and can be attributed to many causes. A karyotype (chromosomal analysis) is not indicated as an initial test for amenorrhea as it is not a screening test. However, it is indicated to further evaluate the etiology of an elevated follicle-stimulating hormone in a woman under 40 years of age or in the presence of physical findings suggestive of disorders of sexual development.

Sponsoring Organizations

• American Society for Reproductive Medicine

Sources

• Expert consensus

Disciplines

• Gynecologic

References

• Baker VL. Primary ovarian insufficiency in the adolescent. Curr Opin Obstet Gynecol. 2013 Oct;25(5):375-81.
  
• Nelson LM, Covington SN, Rebar RW. An update: spontaneous premature ovarian failure is not an early menopause. Fertil Steril. 2005 May;83(5):1327–32.
  
• Bachmann GA, Kemmann E. Prevalence of oligomenorrhea and amenorrhea in a college population. Am J Obstet Gynecol. 1982 Sep 1;144(1):98–102.
  
• Reindollar RH, Byrd JR, McDonough PG. Delayed sexual development: a study of 252 patients. Am J Obstet Gynecol. 1981 Jun 15;140(4):371–80.
  
• Reindollar RH, Novak M, Tho SP, McDonough PG. Adult-onset amenorrhea: a study of 262 patients. Am J Obstet Gynecol. 1986 Sep;155(3):531–43.
  
• Klein DA, Poth MA. Amenorrhea: an approach to diagnosis and management. Am Fam Physician. 2013 Jun 1;87(11):781–8.