• Rationale and Comments

    The benefit of fluoride-containing toothpaste arises from its topical effect on dental enamel by interrupting enamel demineralization caused by bacterial acids and enhancing remineralization of the enamel surface. Anti-caries (anti-cavities) benefit begins with eruption of the first primary tooth. Brushing with nonfluoridated toothpaste provides no anti-caries benefit. Use of recommended amounts of fluoride toothpaste minimizes risks of fluorosis, a whitish discoloration of enamel.

    Sponsoring Organizations

    • American Dental Association


    • Systematic review


    • Pediatric
    • Preventive Medicine


    • American Academy of Pediatric Dentistry. Guideline on Fluoride Therapy. Pediatr Dent 2014;36(6): 171-74.
    • American Dental Association Council on Scientific Affairs. Fluoride toothpaste use for young children. J Am Dent Assoc. 2014 Feb;145(2):190-1.
    • Wright JT, Hanson N, Ristic H, Whall CW, Estrich CG, Zentz RR. Fluoride toothpaste efficacy and safety in children younger than 6 years: a systematic review. J Am Dent Assoc. 2014 Feb;145(2):182-9.