• Rationale and Comments

    There is no indication for supplementing with B vitamins in patients with polyneuropathy unless a deficiency has been detected or is highly likely secondary to other medical factors (e.g., gastric bypass surgery). In addition to being an unnecessary expense, excessive vitamin B-6 can lead to toxicity and cause worsening neuropathy.

    Sponsoring Organizations

    • American Association of Neuromuscular & Electrodiagnostic Medicine


    • Expert consensus


    • Neurologic


    • Bril V et al. Neurology. 2011 May 17;76(20):1758-65.
    • Kulkantrakorn K. Neurol Sci. 2014 Nov;35(11):1827-30.
    • Pluijims et al. Pain Pract. 2011 Mar-Apr;11(2):191-8.