Rationale and Comments

Due to serious potential side effects associated with the use of fluoroquinolone antibiotics, these drugs should not be prescribed as first-line therapy for uncomplicated cystitis in women. Their use should be reserved for situations where recommended first-line antibiotic therapies, such as nitrofurantoin or sulfa-trimethoprim, are contraindicated.

Sponsoring Organizations

• American Urological Association

Sources

• Expert consensus

Disciplines

• Infectious disease
• Urologic

References

• FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together, July 26 2016; www.fda.gov/Drugs/DrugSafety/ucm500143.htm.
  
• International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis (2011) 52 (5): e103-e120. DOI: doi.org/10.1093/cid/ciq257; www.idsociety.org/uploadedFiles/IDSA/Guidelines-Patient_Care/PDF_Library/Uncomp%20UTI.pdf.