• Rationale and Comments

    Premature adrenarche is usually the diagnosis and does not involve activation of the pituitary-gonadal axis but is due to an early increase in adrenal androgens. DHEA-S levels are elevated for age but do not alter the management of this common and generally benign condition.

    Sponsoring Organizations

    • American Academy of Pediatrics – Section on Endocrinology


    • American Academy of Pediatrics guidelines


    • Endocrinologic
    • Pediatric


    • Kaplowitz P, Bloch C, the SECTION ON ENDOCRINOLOGY. Evaluation and Referral of Children with Signs of Early Puberty. Pediatrics. 2016;137(1):e20153732.