Alcohol and other withdrawal seizures occur due to abrupt cessation in a person who is substance-dependent, and can usually be readily identified by the clinical scenario. Once the acute detoxification is complete, anti-epileptic drugs are not indicated. It is, however, important to identify scenarios where there is increased risk of epilepsy, such as prior epilepsy diagnosis, acute intoxication related brain injury, and seizures with history of alcohol use but without acute withdrawal.