The ANA has a high sensitivity for only one disease, systemic lupus erythematosus, but has very poor specificity for systemic lupus erythematosus and every other rheumatic disease. Therefore, it is not useful or indicated as a general screen of autoimmunity. A positive ANA may occur secondary to polyclonal activation of the immune system following an infection, or it may be positive without any identifiable reason/disease in up to 32% of the population. Limiting patients on which to order ANA would reduce unnecessary physician visits and laboratory expenses, as well as parental anxiety. “Lupus panels” and other similar panels should also not be ordered without concerns for specific autoimmune disease. Additionally, since the ANA may always be positive and may fluctuate in titer, it is not recommended to retest it unless there is some new clinical concern.