Urine cultures should only be requested from patients who have clinical signs of UTI. Routine culture of urine in asymptomatic individuals may detect asymptomatic bacteriuria, which is commonly found in certain populations. Screening for asymptomatic bacteriuria has no clinical benefit and may result in harm. Testing for asymptomatic bacteriuria should only be pursued in specific populations such as pregnant women and individuals who are about to undergo urologic procedures that involve mucosal disruption.