• Rationale and Comments

    Use of diphenhydramine (or other first generation antihistamines), benzodiazepines, or sedative hypnotics with anticholinergic side effects should be avoided, as the data suggests these drugs may cause confusion and delirium in the short term, and some have been associated with an increased risk of dementia with long-term use. These drugs are associated with a five-fold increase in adverse cognitive events, an increase in adverse psychomotor events, and are associated with an increased risk of falls. The 2019 updated Beers criteria for potentially inappropriate medications for use in older adults recognized these medications as problematic.

    Sponsoring Organizations

    • Society for Post-Acute and Long-Term Care Medicine


    • Randomized controlled trials


    • Geriatric Medicine
    • Psychiatric and Psychologic


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