• Rationale and Comments

    Diabetic peripheral neuropathy is a progressive condition that may be painful or painless. Neuropathic pain agents (e.g., anticonvulsants, antidepressants) have been studied to reduce painful symptoms in those with neuropathy; however, they have no effect on painless neuropathy and their many side effects can cause unnecessary harm (e.g., unwanted drug interactions, increased fall risk).

    Sponsoring Organizations

    • American Podiatric Medical Association


    • American Academy of Neurology guidelines


    • Endocrinologic
    • Neurologic


    • Bril V, England JD, Franklin GM, et al. Evidence-based guideline: treatment of painful diabetic neuropathy--report of the American Association of Neuromuscular and Electrodiagnostic Medicine, the American Academy of Neurology, and the American Academy of Physical Medicine & Rehabilitation. Muscle Nerve. 2011;43(6):910-917.
    • Benbow SJ, Chan AW, Bowsher D, et al. A prospective study of painful symptoms, small-fibre function and peripheral vascular disease in chronic painful diabetic neuropathy. Diabet Med. 1994;11(1):17-21.