• Rationale and Comments

    In patients with low pretest probability of venous thromboembolism as defined by the Wells prediction rules, a negative high-sensitivity D-dimer measurement effectively excludes venous thromboembolism and the need for further imaging studies.

    Sponsoring Organizations

    • American College of Physicians


    • American Academy of Family Physicians
    • American College of Physicians
    • American College of Emergency Physicians guidelines


    • Pulmonary medicine


    • American College of Emergency Physicians. Evaluation and management of adult emergency department patients with suspected pulmonary embolism. January 2011. http://www.acep.org/Content.aspx?id=80332.
    • 2008 European Society of Cardiology. Acute pulmonary embolism (diagnosis and management of). 2008. http://www.escardio.org/guidelines-surveys/esc-guidelines/Pages/acute-pulmonary-embolism.aspx.
    • Snow V, et al. Management of venous thromboembolism. Ann Intern Med. 2007;146:204-10.
    • Scottish Intercollegiate Guidelines Network. Prevention and management of venous thromboembolism.