Medication		Colon activity	Small-bowel activity	Dosage range*	Approximate cost per month (generic)†	Relative side effect risk‡
5-Acetylsalicylic acid compounds
	Sulfasalazine (Azulfidine)	+++	+	2 to 4 g per day	$49 (23-26) for 180 500-mg tablets	Intermediate
	Olsalazine (Dipentum)	+++	+	1 to 3 g per day	$124 for 180 250-mg tablets	Low to intermediate
	Mesalamine (Pentasa)	++	++	2 to 4 g per day	$105 for 180 250-mg capsules	Low
	Mesalamine (Asacol)	+++	+	1.6 to 4.8 g per day	$111 for 180 400-mg tablets	Low
	Mesalamine enema (Rowasa)	+++		4 g per day	$93 for 30 4-g enemas	Very low
Metronidazole (generic)		++	++	750 to 1,500 mg per day	$22-26 for 120 250-mg tablets	Intermediate
Prednisone (generic)		+++	+++	10 to 50 mg per day	$5-6 for 100 10-mg tablets	Very high
Corticosteroid enema (Cortenema)		+++		One enema (100 mg) per day	$229 for 30 100-mg enemas	Low (but avoid long-term use)
Mercaptopurine (Purinethol)		+++	+++	50 to 100 mg per day	$61 for 50 50-mg tablets	High
Methotrexate (Rheumatrex)		+++	+++	15 to 25 mg per week	$289 (225–262) for 75 2.5-mg tablets	High
					$14 for 2 50-mg vials