Drug	Symptoms and physical findings	Laboratory findings
Acetaminophen (Tylenol)	Nausea, vomiting, malaise, right upper quadrant abdominal pain, jaundice, confusion, somnolence; coma may develop later	After 24 hrs, increased AST (>1,000 IU/L is characteristic), increased ALT, increased bilirubin, PT may increase
Salicylates	Nausea, vomiting, hyperpnea, tinnitus, fever, disorientation, lethargy, coma, seizures, diaphoresis, abdominal pain	Respiratory alkalosis with progressive anion-gap metabolic acidosis, hyperglycemia/hypoglycemia, hypernatremia/hyponatremia, hypokalemia
Cyclic antidepressants	CNS excitability, confusion, blurred vision, dry mouth, fever, mydriasis, seizures, coma, arrhythmias, hypotension, tachycardia, respiratory depression; physical condition can rapidly change	ECG findings of increased QRS interval > 0.10 seconds, sinus tachycardia, conduction abnormalities
Benzodiazepines	Drowsiness, lethargy, dysarthria, ataxia, hypotension, hypothermia, coma, respiratory depression with severe overdoses	No characteristic findings
Cocaine	Anxiety, euphoria, nausea, headache, chest pain, fever, hypertension, tachypnea, tachycardia, vomiting, agitation, mydriasis, diaphoresis, twitching, confusion, hallucinations, abdominal cramps, seizures, hypotension, dysrhythmias, cardiopulmonary arrest	Positive for conditions caused by cocaine poisoning, including myocardial infarction
Calcium channel blockers	Drowsiness, confusion, chest pain, hypotension, bradycardia, peripheral cyanosis, coma, seizures, respiratory distress	ECG findings of first-, second- or third-degree heart block, metabolic acidosis, hyperglycemia, pulmonary edema
Narcotics	Drowsiness, nausea, vomiting, miosis, respiratory depression, cyanosis, coma, seizures, bradypnea, noncardiac pulmonary edema	With severe respiratory depression, hypoxemia, hypercarbia, respiratory acidosis, rhythm disturbances, pulmonary edema