Agent	Formulation	FDA-approved indications	Dosage forms (mg)	Initial dosage	Maximum dosage	Dosing comments
Mibefradil	Immediate release	Hypertension, angina	50-, 100-mg tablets	50 mg daily	100 mg daily	Take with or without food
Verapamil	Immediate and sustained release	Hypertension, supraventricular tachycardia, angina	Immediate release: 40-, 80-, 120-mg tablets; sustained release: 120-, 180-, 240-mg tablets or caplets	Immediate release: 40 mg three times daily; sustained release: 120 to 180 mg daily*	Immediate release: 480 mg daily; sustained release: 240 mg twice daily or 480 mg daily*	Immediate release: take with or without food; sustained release: take with food or at bedtime*
Diltiazem	Immediate and sustained release	Hypertension, angina	Immediate release: 30-, 60-, 90-, 120-mg tablets; sustained release: 60-, 90-, 120-, 180-, 240-, 300-, 360-mg capsules	Immediate release: 30 mg four times daily; sustained release: 120 or 180 mg daily*	Immediate release: 360 mg daily; sustained release: 360, 480 or 540 mg daily*	Immediate release: take before meals; sustained release: take with or without food or on empty stomach*
Nifedipine	Immediate and sustained release	Hypertension, angina	Immediate release: 10-, 20-mg capsules; sustained release: 30-, 60-, 90-mg tablets	Immediate release: 10 mg three times daily; sustained release: 30 mg daily	Immediate release: 180 mg daily; sustained release: 90 or 120 mg daily*	Immediate release: take with or without food; sustained release: take with or without food or on empty stomach*
Amlodipine	Immediate release	Hypertension, angina	2.5-, 5-, 10-mg tablets	5 mg daily (in rare cases, 2.5 mg daily)	10 mg daily	Take with or without food
Felodipine	Extended release	Hypertension	2.5-, 5-, 10-mg tablets	5 mg daily	10 mg daily	Bioavailability doubles when taken with grapefruit juice
Isradipine	Immediate release	Hypertension	2.5-, 5-mg capsules	2.5 mg twice daily	20 mg daily	Take with or without food
Nicardipine	Immediate and sustained release	Immediate release: angina; sustained release: hypertension	Immediate release: 20-, 30-mg capsules; sustained release: 30-, 45-, 60-mg capsules	Immediate release: 20 mg three times daily; sustained release: 30 mg twice daily	Immediate release: 90 mg daily; sustained release: 120 mg daily	Take on empty stomach
Nisoldipine	Extended release	Hypertension	10-, 20-, 30-, 40-mg tablets	20 mg daily	60 mg daily	Avoid taking with high-fat meal
Nimodipine	Immediate release	Subarachnoid hemorrhage	30-mg capsules	60 mg four times daily	60 mg four times daily	Liquid-filled capsule; may go down nasogastral tube
Bepridil	Immediate release	Angina	200-, 300-, 400-mg tablets	200 mg daily	400 mg daily	May take with food