Nonnucleoside reverse transcriptase Inhibitor	Interacting drug	Effect of nonnucleoside reverse transcriptase inhibitor	Comments or recommendations
Nevirapine (Viramune)	Ethinyl estradiol	Decreased ethinyl estradiol levels	Alternative contraception recommended
	Rifampin (Rifadin, Rifamate, Rimactane), rifabutin (Mycobutin)	Decreased rifamycin levels	Unclear whether dosage adjustment is necessary
	Indinavir (Crixivan)	Decreased indinavir levels	Increase indinavir dosage to 1,000 mg every 8 hours
	Saquinavir (Fortovase, Invirase)	Decreased saquinavir levels	Avoid concurrent administration
	Nelfinavir (Viracept)	Decreased nelfinavir levels	Increase nelfinavir dosage to 1,000 mg 3 times daily
Delavirdine (Rescriptor)	Astemizole (Hismanal), terfenadine (Seldane)	Antihistamine-related cardiac arrhythmias	Contraindicated
	Cisapride (Propulsid)	Cisapride-related cardiac arrhythmias	Contraindicated
	Rifabutin	Increased rifabutin levels, decreased delavirdine levels	Avoid concurrent administration
	Rifampin	Decreased delavirdine levels	Avoid concurrent administration
	Benzodiazepines	Accumulation of drug, leading to prolonged sedation	Avoid specific agents: alprazolam (Xanax), midazolam (Versed), triazolam (Halcion)
	Anticonvulsants	Decreased delavirdine levels	Avoid specific agents: carbamazepine (Tegretol), phenytoin (Dilantin), phenobarbital
	Indinavir	Increased indinavir levels	Reduce indinavir dosage to 400 to 600 mg every 8 hours
	Saquinavir	Increased saquinavir levels	No dosage adjustment needed