Drug		Dosage	Side effects/comments
NSAIDS (selected)			Contraindicated in patients with peptic ulcer disease or systemic anticoagulation; side effects include gastropathy, nephropathy, liver dysfunction, central nervous system dysfunction and reversible platelet dysfunction; may cause fluid overload in patients with congestive heart failure
	Indomethacin (Indocin)	25 to 50 mg four times daily
	Naproxen (Naprosyn)	500 mg two times daily
	Ibuprofen (Motrin)	800 mg four times daily
	Sulindac (Clinoril)	200 mg two times daily
	Ketoprofen (Orudis)	75 mg four times daily
Colchicine		0.5 to 0.6 mg orally every hour until relief or side effects occur, or until a maximum dosage of 6 mg is reached	Dose-dependent gastrointestinal side effects; improper intravenous dosing has caused bone marrow suppression, renal failure and death (see text)
Corticosteroids
	Oral	Prednisone, 0.5 mg per kg on day 1, taper by 5.0 mg each day thereafter	Fluid retention; impaired wound healing
	Intramuscular	Triamcinolone acetonide (Kenalog), 60 mg intramuscularly, repeat in 24 hours if necessary	May require repeat injections; risk of soft tissue atrophy
	Intra-articular	Large joints: 10 to 40 mg*	Preferable route for monoarticular involvement
		Small joints: 5 to 20 mg*
	ACTH†	40 to 80 IU intramuscularly; repeat every 8 hours as necessary	Repeat injections are commonly needed; requires intact pituitary-adrenal axis; stimulation of mineralocorticoid release may cause volume overload