Route of administration	Replacement therapy	Maintenance therapy
Intramuscular	1,000 μg daily for five days, then 1,000 mg weekly for four weeks	1,000 μg every one to three months
Oral	1,000 to 2,000 μg daily	25 to 100 μg daily25
Intranasal	1,500 μg weekly for three to four weeks*	500 μg weekly