Vaccination status	Treatment	Regimen*
Not previously vaccinated	Wound cleansing	All postexposure treatment should begin with immediate thorough cleansing of all wounds with soap and water. If available, a virucidal agent such as a povidone-iodine solution should be used to irrigate the wounds.
	RIG	Administer 20 IU per kg body weight. If anatomically feasible, the full dose should be infiltrated around the wound(s) and any remaining volume should be administered intramuscularly at an anatomic site distant from vaccine administration. Also, RIG should not be administered in the same syringe as vaccine. Because RIG might partially suppress active production of antibody, no more than the recommended dose should be given.
	Vaccine	HDCV, RVA or PCEC, 1.0 mL intramuscularly (deltoid area†), one each on days 0,‡ 3, 7, 14 and 28.
Previously vaccinated§	Wound cleansing	All postexposure treatment should begin with immediate thorough cleansing of all wounds with soap and water. If available, a virucidal agent such as a povidone-iodine solution should be used to irrigate the wounds.
	RIG	RIG should not be administered.
	Vaccine	HDCV, RVA or PCEC, 1.0 mL intramuscularly (deltoid area†), one each on days 0‡ and 3.