Drug	Efficacy	Ease of use	Side effects	Cost*	Comment
Intracavernosal alprostadil (Caverject)	Significantly greater than placebo	Injected via syringe into penis	Penile pain; hematoma; priapism	$155 for box of 6 doses of 20 μg	Method of delivery may limit compliance
Transurethral alprostadil (MUSE)	Significantly greater than placebo	Inserted into urethra	Penile pain	$133 for box of 6 doses of 500 μg	Method of delivery may limit compliance
Sildenafil (Viagra)	Significantly greater than placebo	Taken orally one hour before anticipated intercourse	Headache; flushing; dyspepsia	$263 for 30 tablets of any size	Avoid use with nitrates