The total daily insulin dosage is 0.3 unit per kg of body weight.

Twice-daily administration of NPH insulin and regular insulin usually works adequately while endogenous insulin is still being produced.

Two thirds of the total daily insulin dose may be given 20 to 30 minutes before breakfast, and one third of the dose may be given 20 to 30 minutes before the evening meal.

As an estimate, NPH insulin and regular insulin can be given in a 2:1 ratio for the breakfast dose and a 1:1 ratio for the evening-meal dose.

As more complete insulin deficiency develops, this regimen becomes less effective.