Drug	Route	Headache response rate (%) Adverse reactions (%)
		At 2 hours post-dose	At 4 hours post-dose	Taste disturbance	Paresthesia, burning sensation	Chest pain, chest tightness
DHE (Migranal), 2 mg11	Nasal	30 to 61	47 to 70	8	2	—
Placebo	—	20 to 23	22 to 35	1	2	—
Sumatriptan (Imitrex nasal), 5 mg12	Nasal	45 to 49	—	19 to 24	0.4	—
Sumatriptan, 20 mg	Nasal	55 to 64	—	25 to 36	1.4	—
Placebo	—	25 to 36	—	0 to 2	0.1	—
Sumatriptan (Imitrex), 25 mg13	Oral	52	65 to 70	—	3	6
Sumatriptan, 50 mg	Oral	50 to 61	68 to 78	—	5	6
Sumatriptan, 100 mg	Oral	56 to 62	71 to 79	—	3	8
Placebo	—	17 to 27	19 to 38	—	2	4
Sumatriptan (Imitrex Statdose), 6 mg14	Injectable	81 to 82	—	—	7.5	4.5
Placebo	—	31 to 39	—	—	0.3	1.4
Naratriptan (Amerge), 1 mg15	Oral	42	50 to 54	—	1	2
Naratriptan, 2.5 mg	Oral	45 to 51	60 to 66	—	2	4
Placebo	—	31	27 to 34	—	< 1	2
Rizatriptan (Maxalt), 5 mg16	Oral	60 to 63	—	—	3	< 2
Rizatriptan, 10 mg	Oral	67 to 77	—	—	4	3
Placebo	—	23 to 40	—	—	< 2	1
Zolmitriptan (Zomig), 2.5 mg17	Oral	62 to 65	73	—	7	3
Zolmitriptan, 5 mg	Oral	59 to 67	77	—	9	4
Placebo	—	16 to 44	40		2	1