Drugs	Comments
Psychotropics
Amitriptyline (Elavil)	Strongly anticholinergic and sedating
Barbiturates	More side effects than most sedative-hypnotic drugs; should not be used except to control seizures (phenobarbital)
Long-acting benzodiazepines	Long half-life and, hence, prolonged sedation; associated with an increased incidence of falls and fractures
Doxepin (Sinequan)	Strongly anticholinergic and sedating
Meprobamate (Miltown)	Highly addictive and sedating
Analgesics
Meperidine (Demerol)	Not effective when administered orally; metabolite has anticholinergic profile
Pentazocine (Talwin)	Confusion and hallucinations more common than with other narcotics
Miscellaneous
Antispasmodic agents (gastrointestinal)	Highly anticholinergic with associated toxic effects
Chlorpropamide (Diabinase)	Serious hypoglycemia possible because of the drug's prolonged half-life
Digoxin (Lanoxin)	Decreased renal clearance; doses should rarely exceed 0.125 mg except when treating arrhythmias
Methyldopa (Aldomet)	Causes bradycardia and exacerbates depression
Ticlopidine (Ticlid)	More toxic than aspirin