Neurotransmitter	Affected receptors	Clinical effects
Acetylcholine	Nicotinic and muscarinic receptors	Coordination, new memory, rapid-eye-movement sleep, affective expression, cognitive function
Dopamine	DA receptors	Cognitive integration, motor activity initiation, working memory
GABA	GABA receptors	Inhibitory transmission of cortex; functions of cerebellum, hippocampus and limbic system
Norepinephrine	α1, α2, β1 and β2 receptors	Sleep maintenance, mood modulation
Opioids	δ, κ ε, and μ receptors	Analgesia, euphoria, sedation, respiratory depression, hypothermia
Serotonin	All 5-HT receptors	Sleep initiation, mood modulation, pain modulation, modulation of aggression, control of anxiety, maintenance of alertness