Interacting drug	Celecoxib	Rofecoxib
Methotrexate (Rheumatrex)	No	Yes*
Warfarin (Coumadin)	No	Yes†
Ketoconazole (Nizoral)	No	No
Lithium	Yes‡	NA
Fluconazole (Diflucan)	Yes§	NA
Glyburide (Micronase)	No	NA
Phenytoin (Dilantin)	No	NA
Tolbutamide (Orinase)	No	NA
Rifampin (Rifadin)	NA	Yes∥
Digoxin (Lanoxin)	NA	No
Oral contraceptives	NA	No