Drugs that increase the serum digoxin concentration by reducing clearance or volume of distribution:
Alprazolam (Xanax)
Amiodarone (Cordarone)
Indomethacin (Indocin)
Propafenone (Rythmol)
Quinidine
Verapamil (Calan)
Drugs that increase the serum digoxin concentration by reducing inactivation by bacterial metabolism in the intestines:
Clarithromycin (Biaxin)
Erythromycin
Tetracycline
Drugs that increase the serum digoxin concentration by decreasing intestinal motility and increasing absorption:
Diphenoxylate (with atropine; Lomotil)
Propantheline (Pro-Banthine)
Drugs that decrease the serum digoxin concentration by decreasing absorption:
Antacids
Cholestyramine (Questran)
Metoclopramide (Reglan)
Neomycin
Drugs that decrease the serum digoxin concentration by increasing nonrenal clearance:
Rifampin (Rifadin)