Blood lead level,μg per dL (μmol per L)Intervention
< 25 (1.20)Environmental intervention
25 to 44 (1.20 to 2.10)Aggressive environmental intervention
Consider oral chelation therapy if blood lead levels persist in this range after environmental intervention.
45 to 69 (2.15 to 3.35)Before chelation therapy is initiated, obtain an abdominal radiograph to look for enteral lead; if lead is present, consider bowel decontamination as an adjunct to treatment.
If no signs of encephalopathy are present, succimer, or DMSA, may be given in a dosage of 30 mg per kg per day for 5 days, followed by 20 mg per kg per day for 14 days; consider hospitalization to monitor for side effects of chelation therapy and to start environmental abatement.
Alternative therapy: inpatient treatment with edetate disodium calcium, or
CaNa2EDTA, in a dosage of 25 mg per kg per day for 5 days
> 70 (3.40)If signs of encephalopathy are present, obtain a consultation; admit the child to an intensive care unit for treatment of increased intracranial pressure, monitoring of mental status and hemodynamic stability, osmotic therapy and drug therapy, in addition to chelation therapy.
Initiate chelation therapy with dimercaprol, or BAL, administered intramuscularly in a dosage of 25 mg per kg per day divided into six doses.
After the second dose of BAL (4 hours after the first dose), immediately administer CaNa2EDTA, 50 mg per kg per day in a single dose given intravenously during several hours or as a continuous slow infusion.*
Continue treatment with BAL and CaNa2EDTA for at least 72 hours.
After initial treatment, parenteral therapy with CaNa2EDTA and BAL or with CaNa2EDTA alone may be continued for a total of 5 days.