Infection	Preferred drug(s)	Alternative drug(s)
Otitis media	Amoxicillin	Amoxicillin-clavulanate (Augmentin), trimethoprim-sulfamethoxazole (Bactrim, Septra), second-generation cephalosporins, some third-generation cephalosporins, macrolide antibiotics
Streptococcal pharyngitis	Penicillin V	In patients with penicillin allergy: macrolide antibiotics, first-generation cephalosporins
Sinusitis	Amoxicillin, trimethoprim-sulfamethoxazole	Amoxicillin-clavulanate, second-generation cephalosporins, third-generation cephalosporins
Animal and human bites	Amoxicillin-clavulanate	Depends on type of bite (e.g., cefuroxime axetil [Ceftin] or doxycycline [Vibramycin] for cat bites)
Bacterial endocarditis prophylaxis	Amoxicillin	In patients with penicillin allergy: clindamycin (Cleocin), cephalexin (Keflex), azithromycin (Zithromax), clarithromycin (Biaxin)
Pneumonia	Macrolide antibiotics, quinolone antibiotics	Amoxicillin-clavulanate, second-generation cephalosporins, third-generation cephalosporins
Bronchitis (controversial)	Doxycycline, trimethoprim-sulfamethoxazole, amoxicillin-clavulanate	Macrolide antibiotics, quinolone antibiotics, second-generation cephalosporins, some third-generation cephalosporins
Skin and soft tissue infections (cellulitis)	First-generation cephalosporins, cloxacillin (Tegopen), dicloxacillin (Dynapen)	Macrolide antibiotics, amoxicillin-clavulanate, cefpodoxime (Vantin), cefdinir (Omnicef)
Urinary tract infection	Quinolone antibiotics, trimethoprim-sulfamethoxazole	Amoxicillin, amoxicillin-clavulanate, cefuroxime axetil or other cephalosporins, doxycycline, nitrofurantoin (Furadantin)