Lesion type	Description
Macule	Circumscribed area of change in normal skin color, with no skin elevation or depression; may be any size
Papule	Solid, raised lesion up to 0.5 cm in greatest diameter
Nodule	Similar to papule but located deeper in the dermis or subcutaneous tissue; differentiated from papule by palpability and depth, rather than size
Plaque	Elevation of skin occupying a relatively large area in relation to height; often formed by confluence of papules
Pustule	Circumscribed elevation of skin containing purulent fluid of variable character (i.e., fluid may be white, yellow, greenish or hemorrhagic)
Vesicle	Circumscribed, elevated, fluid-containing lesion less than 0.5 cm in greatest diameter; may be intraepidermal or subepidermal in origin
Bulla	Same as vesicle, except lesion is more than 0.5 cm in greatest diameter