Clinical features

Amenorrhea, oligomenorrhea or dysfunctional uterine bleeding

Anovulatory infertility

Hirsutism and/or acne

Central obesity

Endocrine abnormalities on laboratory tests

Elevated androgen (i.e., testosterone) levels

Elevated luteinizing hormone concentration with normal to mildly elevated

follicle-stimulating hormone level

Insulin resistance with hyperinsulinemia

Radiologic abnormalities on ultrasound examination

Multiple (nine or more) subcortical follicular cysts

Increased ovarian stromal density and/or volume

Exclusion of other etiologies

Prolactinoma

Virilizing tumors of adrenal or ovarian tumors

Congenital adrenal hyperplasia

Cushing's syndrome