TestFindingPossible etiology
Complete blood count
RBC indicesMCV < 80 μm3 per cell (80 fL)Iron deficiency anemia
Anemia of chronic disease
MCV > 100 μm3 per cell (100 fL)Vitamin B12 deficiency; folate deficiency
MCV normalRenal, liver and thyroid diseases as well as those above
WBC and platelet countsAbnormalPrimary marrow production problem
Peripheral smearBurr cellsChronic renal failure
Spherocytes, fragmentsHemolytic diseases
Dysplastic changesMyelodysplasia
Reticulocyte count< 1%Inadequate production in presence of anemia
≥1%Increased production but unclear whether it is of appropriate magnitude; reticulocyte index helpful for clarification
Reticulocyte index*≥2Reticulocyte release appropriate for anemia
< 2Inadequate response to anemia