Adverse reaction	Tetracycline	Doxycycline (Vibramycin)	Minocycline (Minocin)	Erythromycin
Dyspepsia	X	X	X	X
Vaginal yeast infection	X	X	X	X
Photosensitivity	X	X	X*	X
Possible interference with oral contraceptives	X	X	X
Tooth discoloration in children younger than 13 years or in developing fetuses	X	X	X
Propionibacterium acnes antibiotic resistance	X	X		X
Hyperpigmentation in scars			X
Pseudotumor cerebri	X	X	X
Vestibular toxicity			X
Lupus-like reaction†2			X
Single-organ dysfunction‡2	X	X	X
Hypersensitivity reaction§2	X	X	X
Serum sickness–like reaction∥2	X	X	X