Vital signs

Respiratory depression; hypothermia; bradycardia with increases or decreases in blood pressure

Cardiovascular

Bradycardia; orthostatic hypotension

Respiratory

Respiratory depression; apnea; Cheyne-Stokes respiration

Neurologic

Nystagmus; vertigo; ataxia; weakness; dizziness; sedation; confusion; hallucinations; short-term amnesia; coma, tonic-clonic seizure-like activity

Psychiatric

Aggression; impairment of judgment

Gastrointestinal

Vomiting

Endocrine

Mild hyperglycemia

Acid base

Acute respiratory acidosis