Organism	Exposure history	Diagnosis	Therapy	Alternative therapy	Duration of treatment
Sporothrix schenckii	Gardening, soil contamination, splinters, animal scratches or bites	Biopsy and culture	Itraconazole (Sporanox), 200 mg daily2–4	SSKI, 5 drops in water three times daily, slowly increased to 40 to 50 drops three times daily as tolerated2,5 Terbinafine (Lamisil), 250 mg twice daily4	Two months after resolution of lesions
Nocardia brasiliensis	Gardening, soil contamination, splinters	Biopsy and culture	TMP-SMX (Bactrim, Septra), 2 double-strength tablets three times daily5,6	Minocycline* (Minocin), 200 mg twice daily5–8 See text for additional alternatives.	Three months symptoms
Mycobacterium marinum	Aquariums, fish-handling, swimming in oceans, lakes or pools	Biopsy and culture	Rifampin (Rifadin), 15 mg per kg, daily with ethambutol (Myambutol), 25 mg per kg daily5,9,10	Minocycline*,100 mg twice daily5,9,10 Rifampin, 10 to 15 mg per kg daily, with clarithromycin* (Biaxin), 30 mg per kg daily10	Two to three months after resolution of
Leishmania brasiliensis	Residence in or travel to endemic areas	Biopsy and culture	Stibogluconate sodium, 20 mg per kg daily,5,11,12 or meglumine antimonate, 20 mg per kg daily11,12	Amphotericin B (Fungizone IV), 0.25 to 1.00 mg per kg daily11 See text for additional alternatives.	20 days