Drug or drug class	Terbinafine (Lamisil)	Itraconazole (Sporanox)	Fluconazole (Diflucan)
Benzodiazepines		Concomitant use of midazolam (Versed) and triazolam (Halcion) contraindicated; use of other benzodiazepines not recommended	Avoid concomitant use because of increased risk of sedation.
Cimetidine (Tagamet)	Increased terbinafine levels possible	Decreased itraconazole absorption	Decreased fluconazole levels possible
Gastric pH neutralizers (histamine H2 blockers, proton pump inhibitors, sucralfate [Carafate])		Monitor for treatment failure because of decreased itraconazole absorption with increased gastric pH.
HMG-CoA reductase inhibitors		Concomitant use contraindicated because of reported rhabdomyolysis
Hydrochlorothiazide (Esidrix) and hydrochlorothiazide combinations			Increased fluconazole levels possible
Oral hypoglycemics (all classes)		Increased hypoglycemia possible	Risk of significant hypoglycemia
Quinidines		Concomitant use contraindicated because of reported ventricular arrhythmias
Pimozide (Orap)		Concomitant use contraindicated because of reported ventricular arrhythmias
Rifampin (Rifadin)	Decreased terbinafine levels possible		Decreased fluconazole levels possible
Theophylline			Increased theophylline levels possible
Warfarin (Coumadin)	Bleeding events reported	Increased risk of bleeding	Increased risk of bleeding