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Am Fam Physician. 2001;64(1):149-153

Medical or ethical justification of unrequested nutrition in a terminally ill patient is typically an emotional response to the clinical situation and has not been proved to be clinically beneficial. Winter reviewed the literature to determine the benefits and burdens of nutritional support in terminally ill patients.

The benefit of nutritional support in a terminally ill patient is measured by improvements in the patient's response to therapy, comfort or length of survival. Studies of terminally ill patients with cancer have uniformly shown that treatment with parenteral nutrition provides no survival benefit and does not improve response to chemotherapy. Parenteral nutrition was associated with a higher rate of infection related to the access catheter. Overall, studies—many of them randomized, controlled trials—have consistently failed to demonstrate a meaningful clinical benefit from the use from nutritional support in patients at or near the end of life.

There are many complications of nutritional support administered by an enteral or parenteral route (see accompanying table on page 153). Some of these complications are uncomfortable (nausea, vomiting, diarrhea and agitation) and some are life-threatening.

During a fasting state, fat replaces carbohydrates as the energy substrate, with amino acids as the primary source of energy for brain metabolism. As fasting continues beyond a week, the brain begins to use ketones for energy. Less use of amino acids reduces the urea load to the kidneys. Studies have also shown that fasting patients have less coughing, nausea, vomiting, diarrhea and respiratory secretions. Prolonged fasting, associated with higher ketone levels, causes reduced hunger. Studies of persons fasting for spiritual inspiration or weight loss have demonstrated a state of euphoria. A study of mentally aware and competent patients who were offered unlimited food and drink reported no hunger in 20 patients (63 percent) and mild hunger only at the beginning of the study in 11 patients (43 percent). There is no evidence that the patients had suffering caused by their self-chosen food refusal.

The 1983 President's Commission for the Study of Ethical Problems in Medicine and Biomedical Research (1983) held that physicians are not ethically required to provide futile treatments to patients. One definition of futile treatments is those that fail to provide “improvement in the patient's prognosis, comfort, well-being or general state of health.” Within the context of this definition and based on the available evidence, Winter states that nutritional support is futile in terminally ill patients and that physicians are not obligated to provide such treatment. Winter adds that unrequested nutritional support should not be considered an appropriate aspect of comfort care at the end of life.

In an accompanying editorial, Brody concurs that it is not ethically acceptable to offer patients a therapy that has no apparent benefit and may carry substantial risk. Artificial nutrition and hydration are “life-sustaining” treatments only if such therapy has a proven beneficial effect but, based on the available evidence, this does not seem to be the case.

Parenteral (catheter-related)
Pneumothorax
Hydrothorax
Sepsis
Catheter site infection
Venous thrombosis
Enteral
Agitation
Epistaxis
Nasal alar necrosis
Aspiration pneumonia
Airway obstruction
Nasopharyngitis
Esophagitis
Esophageal stricture
Intestinal obstruction
Abdominal distention
Nausea
Vomiting
Diarrhea
Both
Hyperglycemia
Hypophosphatemia
Hypomagnesemia
Hypercalcemia
Nonketotic hyperosmolar state
Refeeding syndrome
Hepatic steatosis
Steatohepatitis
Intrahepatic cholestasis
Cholelithiasis
Acalculous cholecystitis
Biliary sludge

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