Hypertensive disorders complicate 6 to 8 percent of pregnancies and are a leading cause of maternal and fetal morbidity and mortality.1 Important advances in knowledge in this field and the diverse opinions promulgated by different groups1–4 led the National Heart, Lung, and Blood Institute to establish a Working Group on high blood pressure in pregnancy. The group included broad representation, including the American Academy of Family Physicians. This article summarizes the group's findings,5 focusing on issues of greatest interest to family physicians.
The Working Group identified four hypertensive disorders of pregnancy: chronic hypertension, in which blood pressure elevation is documented before the 20th week of pregnancy; preeclampsia-eclampsia, a syndrome peculiar to pregnancy characterized clinically by hypertension and proteinuria; preeclampsia superimposed on chronic hypertension; and gestational hypertension, and nonproteinuric hypertension that develops in the latter half of pregnancy.5
This scheme and the criteria for each category differ importantly from older diagnostic schemes6 and the current schemes of other groups.1,2,4 Key features of the preeclampsia category include: (1) elimination of a change in blood pressure as a diagnostic criterion (the group recommends using the familiar cut-off of 140/90 mm Hg instead); (2) elimination of edema as a criterion, because this finding is so common in healthy pregnant women; and (3) absolute requirement of proteinuria (more than 300 mg per 24 hours [0.3 g per day]) for the diagnosis. The gestational hypertension category is used in women with nonproteinuric hypertension of pregnancy, in which the pathophysiologic perturbations of the preeclampsia syndrome do not develop before delivery.
Preeclampsia is characterized by widespread physiologic changes, including vasospasm, activation of the coagulation system and disturbances in the humoral and autocoid systems.5 These changes result in ischemic changes in the placenta, kidney, liver and brain, as well as a risk for bleeding complications. The hypertension of preeclampsia can contribute to immediate consequences, such as cerebral hemorrhage; however, it is principally considered a diagnostic sign of the perturbed physiology, because serious maternal or fetal complications can occur even if the blood pressure elevation is mild. Although the specific mechanism of eclamptic seizures is not known, these seizures appear to be the result of more than simple hypertensive encephalopathy. Preeclampsia may be associated with a number of laboratory findings (Table 1).5
Women who are first noted to be hypertensive in the second half of pregnancy present a sizable diagnostic challenge.5 This group may be divided into three diagnostic categories: (1) women with previously undiagnosed chronic hypertension who present late for prenatal care; (2) women with mild preeclampsia who have not yet developed noticeable pathophysiologic perturbations; and (3) women with transient hypertension of pregnancy, in whom the derangements of preeclampsia will not develop and whose blood pressure will normalize by 12 weeks postpartum. Transient hypertension is always a retrospective diagnosis.5
|Hemoglobin and hematocrit||Hemoconcentration supports diagnosis of preeclampsia and is an indicator of severity. Values may be decreased, however, if hemolysis accompanies the disease.|
|Platelet count||Thrombocytopenia <100 × 103 per μL (100 × 109 per L) suggests severe preeclampsia.|
|Quantification of protein excretion||Pregnancy hypertension with proteinuria should be considered preeclampsia (pure or superimposed) until proved otherwise.|
|Serum creatinine||Abnormal or rising levels, especially when associated with oliguria, suggest severe preeclampsia.|
|Serum uric acid||Increased levels suggest the diagnosis of preeclampsia.|
|Serum transaminase||Rising values suggest severe preeclampsia with hepatic involvement.|
|Serum albumin, lactic acid dehydrogenase (LDH), blood smear and coagulation profile||In women with severe disease, these values indicate extent of endothelial leak (albumin), presence of hemolysis (LDH increase, schistocytosis, spherocytosis) and possible coagulopathy.|
The Working Group has intentionally chosen a strict definition of preeclampsia: proteinuric hypertension that develops late in pregnancy. The group advises that the diagnosis is “highly suspect” in hypertensive patients without proteinuria if they have headache, blurred vision, abdominal pain or abnormal laboratory results such as low platelet counts and abnormal liver enzyme levels.5 Because of the serious nature of preeclampsia and the difficulties in its diagnosis, the report recommends that clinicians maintain a high degree of suspicion. The report also recommends obtaining the baseline laboratory studies shown in Table 2 in early pregnancy for women at the highest risk for preeclampsia (Table 3).5
|Serum uric acid|
|24-hour collection for urine protein (if random dipstick measurements are 1+ or greater)|
|Sonographic determination of gestational age as early as possible in pregnancy (if conditions for clinical dating are not optimal)*|
Chronic Hypertension in Pregnancy
Because target organ damage, especially renal disease, can progress during pregnancy, assessment for ventricular hypertrophy, retinopathy and renal disease should be considered in women with a history of hypertension for more than several years.5 Women should be informed of the sizable (25 percent) risk of superimposed preeclampsia5 and its attendant risks, particularly preterm delivery.
Most hypertensive women of childbearing age have stage I or II hypertension (systolic blood pressure of 140 to 179 mm Hg or diastolic blood pressure of 90 to 109 mm Hg) without target organ damage, in which the risk for acute cardiovascular consequences during pregnancy is very low.5,7 Improved maternal or neonatal outcomes with antihypertensive therapy have not been documented in this group.8,9 Accordingly, the Working Group advises that antihypertensive medication might be safely withheld in such patients, provided that blood pressure remains less than 150 to 160 mm Hg systolic and 100 to 110 diastolic while the patient is off medications.5 Continuing previous antihypertensive medication is another option, although angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers should not be used during pregnancy.5 Because methyldopa (Aldomet) has the longest track record of safety in pregnancy,10,11 it is preferred by many clinicians.5
|History of increased blood pressure before conception or in a previous gestation, especially before week 34 or when the patient is multiparous|
|Collagen vascular disease|
|Underlying renal vascular or renal parenchymal disease|
RECOGNITION OF SUPERIMPOSED PREECLAMPSIA
The recognition of preeclampsia superimposed on chronic hypertension is challenging.5 In addition to suspecting the condition if preeclamptic symptoms or laboratory abnormalities develop, superimposition should be suspected when any one of the following is present: (1) blood pressure elevations are severe (greater than 160/110 mm Hg); (2) heavy proteinuria (more than 2,000 mg per 24 hours [2 g per day]) develops or proteinuria abruptly worsens; (3) blood pressure suddenly increases after a period of good control; or (4) serum creatinine increases to more than 1.2 mg per dL (110 μmol per L).5
FETAL ASSESSMENT IN CHRONIC HYPERTENSION
Antepartum fetal assessment is used to facilitate early recognition of fetal compromise related to the development of superimposed preeclampsia.5 If such suspicion is absent, specific fetal assessment is less essential. Initial sonography should be performed at 18 to 20 weeks' gestation. Further fetal growth can usually be monitored by using fundal height measurements, but if maternal obesity or other factors render this measurement inaccurate, repeat sonograms should be obtained monthly starting at 28 to 32 weeks' gestation. If growth restriction or preeclampsia is documented or suspected, the fetal nonstress test (NST) or a biophysical profile (BPP) is indicated.
Antihypertensive medication may be required if blood pressure elevation persists postpartum.5 In women who were not previously known to be hypertensive, a trial off medication for three to four weeks after delivery is reasonable. Little information is available on the effects of antihypertensive medication during lactation. For this reason, withholding antihypertensive medications for several months is acceptable in most patients with stage I and, perhaps, stage II hypertension.
The definitive treatment for preeclampsia is delivery of the fetus.5 Although this is always appropriate therapy for the mother, it may not be so for the fetus. Fetal surveillance in a pregnancy complicated by preeclampsia should consist of daily fetal movement counts and periodic fetal NST and BPP.5 Weekly or biweekly testing is appropriate in most women, but daily testing is indicated in women with severe disease. Details of fetal assessment are shown in Table 4.5 If the results will affect clinical decision making, amniocentesis for fetal lung maturity can be performed.5
|Gestational hypertension (hypertension only, without proteinuria, normal laboratory testing and absent symptoms)|
|Estimation of fetal growth and amniotic fluid status at time of diagnosis; if normal, repeat testing only if there is significant change in maternal condition.|
|NST at time of diagnosis. If nonreactive, perform a biophysical profile BPP; if BPP 8 or NST is reactive, repeat testing only if there is a significant change in maternal condition|
|Mild preeclampsia (mild hypertension, normal platelet count, liver enzymes and absent maternal symptoms)|
|Estimation of fetal growth and amniotic fluid status at time of diagnosis; if normal, repeat testing every three weeks|
|NST and/or BPP at time of diagnosis; if NST is reactive or if BPP 8, repeat weekly. Testing should be repeated immediately if there is an abrupt change in maternal condition.|
|If estimated fetal weight by ultrasonography is <10th percentile for gestational age or if there is oligohydramnios (amniotic fluid index 5 cm), testing should be performed at least twice weekly|
MATERNAL ASSESSMENT/ANTEPARTUM MANAGEMENT
The goals of maternal assessment are twofold: first, to recognize preeclampsia early, and second, to monitor the mother for evidence of disease progression that would mandate either delivery or more intensive fetal surveillance.5 Once blood pressure elevation is documented during the second half of pregnancy, the patient should be assessed for symptoms of preeclampsia and laboratory evidence of the disease by checking the platelet count, liver enzyme levels and serum creatinine level, and by obtaining a 12- to 24-hour urine collection to check protein level. In the absence of severe preeclampsia, serum albumin and lactic acid dehydrogenase levels, blood smear and coagulation profile need not be checked.
Depending on the patient's clinical condition and the results of laboratory studies, the patient may be managed as an inpatient, in an intensive day-hospitalization program15 (if available) or as an outpatient, possibly with home testing of blood pressure and urinary protein.16 Patients managed as outpatients should be re-evaluated within one to three days. Laboratory studies and fetal surveillance should be followed at frequent intervals. The Working Group indicated that restriction of maternal activity was a “usual and reasonable practice,” but it acknowledged that there was no evidence of efficacy. Evidence that antihypertensive therapy improves perinatal outcomes is also lacking.8,17,18
TIMING AND ROUTE OF DELIVERY
Decisions about the timing of delivery hinge on whether the infant will fare better in utero or in the nursery, and whether the mother's condition will tolerate continued pregnancy. Proposed indications for delivery are presented in Table 5.5 Even if the maternal and fetal conditions appear stable, all women with preeclampsia should be considered for delivery at 38 weeks' gestation if the cervix is favorable, and by 40 weeks if it is not. Delivery should be considered in women with severe preeclampsia after 32 to 34 weeks' gestation. Vaginal delivery is preferred and, if maternal and fetal conditions allow, labor induction should be carried out aggressively when the decision to deliver is made, even if the cervix is unripe.5
|Gestational age 38 weeks if cervix is favorable|
|Platelet count <100 × 103 per μL (100 × 109 per L)|
|Progressive deterioration in liver function|
|Progressive deterioration in renal function|
|Suspected abruptio placentae|
|Persistent severe headaches or visual changes|
|Persistent severe epigastric pain, nausea or vomiting|
|Severe growth restriction|
|Nonreassuring fetal testing results|
Peripartum anticonvulsive therapy is clearly indicated to prevent recurrent seizures in a patient with eclampsia and the emergence of eclampsia in patients with severe preeclampsia.5 Parenteral magnesium sulfate is the drug of choice for this purpose. While magnesium sulfate has also been administered to women with mild preeclampsia and gestational hypertension,19,20 the Working Group considers that its benefits in these groups are uncertain. Intrapartum antihypertensive therapy (Table 6)5 is indicated when sustained blood pressure elevations of 160 mm Hg systolic and/or at least 105 mm Hg diastolic are documented. The goal of blood pressure reduction in emergency situations should be a gradual reduction of blood pressure to the normal range.
POSTPARTUM COUNSELING AND FOLLOW-UP
Hypertension and other signs of preeclampsia should remit by six to 12 weeks' postpartum.5 Women should be informed of the risk of recurrent preeclampsia and its consequences in future pregnancies. Risk factors for recurrence include onset before 30 weeks' gestation (up to 40 percent recurrence), black descent, having a different father from the previous gestation and previous preeclampsia as a multipara. Women with clear-cut, isolated preeclampsia-eclampsia do not appear to have an increased risk of future hypertension or cardiovascular disease, but women with transient hypertension or chronic hypertension do.
Hypertension is a common complication of pregnancy that may have serious consequences to the mother and fetus. When hypertension predates pregnancy, efforts should be directed toward early recognition of intrauterine growth restriction or superimposed preeclampsia, both of which are the most important contributors to adverse outcomes in this group of women. When hypertension develops in the latter half of pregnancy, efforts should focus on distinguishing between probable transient hypertension of pregnancy, by definition a benign and retrospectively diagnosed condition, and preeclampsia-eclampsia. Laboratory studies and close follow-up play the most important role in this distinction. The timing of delivery is the most important management decision, and the physician should carefully weigh maternal and fetal risks.
|Blood pressure 160 mm Hg systolic and/or 105 mm Hg diastolic if sustained|
|Hydralazine (Apresazide): Start with 5 mg IV or 10 mg IM; if blood pressure is not controlled,* repeat at 20-minute intervals (with 5 to 10 mg, depending on response). Once blood pressure control is achieved, repeat as needed (usually about every three hours). If no success by 20 mg IV or 30 mg IM total, consider another drug.|
|Labetalol (Normodyne): Start with 20 mg IV bolus; if effect is suboptimal, give 40 mg 10 minutes later and 80 mg every 10 minutes for two additional doses. Use a maximum of 220 mg. If desired blood pressure levels* are not achieved, switch to another drug. Avoid using labetalol in women with asthma or congestive heart failure.|
|Nifedipine (Procardia)*: Start with 10 mg orally and repeat in 30 minutes if necessary. (Short-acting nifedipine is not approved by the FDA for management of hypertension.)|
|Nitroprusside (Nipride) is rarely needed for treatment of hypertension not responding to the drugs listed above or if there are clinical findings of hypertensive encephalopathy. Start at a rate of 0.25 mg per kg per minute to a maximal dose of 5 mg per kg per minute. Fetal cyanide poisoning may occur if used for more than four hours.|