Mild to moderate exacerbations*
First-line antibiotics
	Doxycycline (Vibramycin), 100 mg twice daily
	Trimethoprim-sulfamethoxazole (Bactrim DS, Septra DS), one tablet twice daily
Amoxicillin-clavulanate potassium(Augmentin), one 500 mg/125 mg tablet three times daily or one 875 mg/125 mg tablet twice daily
Macrolides
	Clarithromycin (Biaxin), 500 mg twice daily
	Azithromycin (Zithromax), 500 mg initially, then 250 mg daily
Fluoroquinolones
	Levofloxacin (Levaquin), 500 mg daily
	Gatifloxacin (Tequin), 400 mg daily
	Moxifloxacin (Avelox), 400 mg daily
Moderate to severe exacerbations†
Cephalosporins
	Ceftriaxone (Rocephin), 1 to 2 g IV daily
	Cefotaxime (Claforan), 1 g IV every 8 to 12 hours
	Ceftazidime (Fortaz), 1 to 2 g IV every 8 to 12 hours
Antipseudomonal penicillins
	Piperacillin-tazobactam (Zosyn), 3.375 g IV every 6 hours
	Ticarcillin-clavulanate potassium (Timentin), 3.1 g IV every 4 to 6 hours
Fluoroquinolones
	Levofloxacin, 500 mg IV daily
	Gatifloxacin, 400 mg IV daily
Aminoglycoside
	Tobramycin (Tobrex), 1 mg per kg IV every 8 to 12 hours, or 5 mg per kg IV daily