Interacting drug	Antidepressant	Potential effect and management
Clonidine (Catapres-TTS)	TCAs	Attenuated antihypertensive effect of clonidine, exaggerated hypertensive response to clonidine withdrawal. Avoid co-administration.
Quinidine (Quinaglute), flecainide (Tambocor), encainide (Enkaid)	TCAs	Prolonged QT interval. Avoid co-administration.
Warfarin (Coumadin)	TCAs, fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft)	Elevates prothrombin time. Monitor INR.
Aspirin, fluoxetine	TCAs	Elevates TCA blood levels. Monitor for signs and symptoms of toxicity.
Metoprolol tartrate (Lopressor), propranolol (Inderal)	Fluoxetine	Bradycardia