Medication		How supplied	Usual initial dose	Single-dose range	Dosage range	Dosage schedule	Peak clinical effect	Onset of behavioral effect	Duration of behavioral effect	Contraindications, monitoring, precautions and adverse effects
Methylphenidate, immediate release
	Generic, Ritalin, Methylin	Tablet: 5, 10 and 20 mg	0.3 to 0.6 mg per kg per dose, or 2.5 to 5 mg	0.3 to 0.8 mg per kg	5 to 80 mg per day	Two or three times daily: full dose given 30 minutes before breakfast and lunch; half-dose given at 3:00 to 4:00 p.m.	Average: 1.9 hours; range: 0.3 to 4 hours	20 to 60 minutes	3 to 6 hours	Contraindications: motor tics, glaucoma, history of seizures, hypertension, pregnancy Recommended monitoring: height, weight, blood pressure, pulse Precautions: avoid decongestants Adverse effects: rebound or deterioration of behavior when medication wears off; emotional lability, irritability, tearfulness, social withdrawal, flattened affect, insomnia, poor appetite, stomach pain, weight loss, reduced growth velocity, headache
Methylphenidate, extended release
	Ritalin-SR	Tablet: 20 mg	20 mg	0.6 to 2 mg per kg, or 20 to 40 mg	20 to 80 mg per day	Once or twice daily	Average: 4.7 hours; range: 1.3 to 8.2 hours	60 to 90 minutes	5 to 8 hours	Same as above Tablets should not be cut in half or crushed.
	Concerta	Tablet: 18 and 36 mg	18 mg	18 mg	18 to 54 mg per day	Once daily	NA	1 to 2 hours	12 hours	Same as above
Dextroamphetamine, immediate release
	Generic, Dexedrine	Capsule: 5, 10 and 15 mg	0.15 mg per kg, or 2.5 to 5 mg	0.15 to 0.5 mg per kg	5 to 40 mg	Two or three times daily	1 to 2 hours	20 to 60 minutes	4 to 6 hours	Same as methylphenidateplus avoid concomitant use with monoamine oxidase inhibitors
	DextroStat	Tablet: 5 and 10 mg
Dextroamphetamine, extended release
	Dexedrine Spansules	Capsule: 5, 10 and 15 mg	5 mg each morning	0.3 to 0.8 mg per kg, or 5 to 20 mg	5 to 40 mg per day	Once or twice daily	NA	60 to 90 minutes	6 to 10 hours	Same as methylphenidate
Amphetamine-dextroamphetamine (Adderall)		Tablet: 5, 10, 20 and 30 mg	2.5 to 5 mg	0.15 to 0.5 mg	2.5 to 40 mg per day	Once or twice daily	1 to 2 hours	30 to 60 minutes	4 to 6 hours	Same as methylphenidate
Pemoline (Cylert)		Tablet: 18.75, 37.5 and 75 mg Chewable tablet: 37.5 mg	18.75 mg each morning	0.5 to 2.5 mg per kg	2 mg per kg, or 18.75 to 112.5 mg per day	Once or twice daily	Variable Steady state in 2 to 3 days Titrate dosage every 3 to 4 weeks.	2 hours (variable)	6 to 10 hours	Informed consent must be obtained before this drug is prescribed. Required monitoring: alanine aminotransferase level at baseline and every 2 weeks; inquire about anorexia, malaise, gastrointestinal symptoms, dark urine. Adverse effects: choreoathetoid movements, liver dysfunction, liver failure, plus same as methylphenidate