Increase replacement requirements
Drugs that reduce thyroid hormone production
	Lithium
	Iodine-containing medications
	Amiodarone (Cordarone)
Drugs that reduce thyroid hormone absorption
	Sucralfate (Carafate)
	Ferrous sulfate (Slow Fe)
	Cholestyramine (Questran)
	Colestipol (Colestid)
	Aluminum-containing antacids
	Calcium products
Drugs that increase metabolism of thyroxine
	Rifampin (Rifadin)
	Phenobarbital
	Carbamazepine (Tegretol)
	Warfarin (Coumadin)
	Oral hypoglycemic agents
Increase thyroxine availability and may decrease replacement requirements
Drugs that displace thyroid hormone from protein binding
	Furosemide (Lasix)
	Mefenamic acid (Ponstel)
	Salicylates