Drug	Dosage	Year of approval
Streptokinase (Streptase)	250,000 U over 30 minutes, then 100,000 U per hour for 24 hours	1977
Urokinase (Abbokinase)	4,400 U per kg over 10 minutes, then 4,400 U per kg per hour for 12 or 24 hours	1978
rtPA	100 mg over 2 hours	1990