Recommended drug: trimethoprim-sulfamethoxazole suspension (Bactrim, Septra).
All dosing regimens use trimethoprim at 150 mg per m2 daily (or 5 mg per kg daily) with sulfamethoxazole at 750 mg per m2 daily (or 25 mg per kg daily)
Recommended dosing regimen: trimethoprim-sulfamethoxazole taken orally twice daily three times a week on three consecutive days (e.g., Monday, Tuesday, Wednesday)
Acceptable alternative dosing regimens for trimethoprim-sulfamethoxazole:
Orally once daily three times a week on three consecutive days
Orally twice daily for one week
Orally twice daily three times a week on alternate days (e.g., Monday, Wednesday, Friday)
Alternative drugs and regimens*:
Dapsone: in infants 1 month of age and older, the dosage is 2 mg per kg taken orally once daily (maximum of 100 mg per dose)
Atovaquone (Mepron): in infants 1 to 3 months of age and young children older than 24 months of age, the dosage is 30 mg per kg daily taken orally; in infants and young children 4 to 24 months of age, the dosage is 45 mg per kg daily taken orally.