Drug and classUsual oral dosingOdds ratio for conversion compared with placebo (95% CI)*
Flecainide (Tambocor): class IC50 mg every 12 hours; increase by 50 mg per day every 4 days to maximum of 300 mg per day.24.7 (CI: 9.0 to 68.3)
Ibutilide (Corvert) given IV, followed by dofetilide (Tikosyn) given orally: both class IIIIbutilide: 0.01 mg per kg IV over 10 minutes; if first dose is not effective, give second infusion 10 minutes later (maximum dose: 1 mg).29.1 (CI: 9.8 to 86.1)
Dofetilide: 0.1 to 0.5 mg every 12 hours
Disopyramide (Norpace): class IA100 to 200 mg every 6 to 8 hours7.0 (CI: 0.3 to 153)
Amiodarone (Cordarone): class III800 to 1,600 mg per day for 7 to 14 days; then 200 to 400 mg per day as maintenance5.7 (CI: 1.0 to 33.4)
Propafenone (Rythmol): class IC150 mg every 12 hours; if needed, increase dose every 3 to 4 days to maximum of 300 mg every 12 hours.4.6 (CI: 2.6 to 8.2)
Quinidines: class IAQuinidine sulfate (Quinidex): 400 mg every 6 hours2.9 (CI: 1.2 to 7.0)
Quinidine gluconate (Quinaglute): 648 mg every 8 to 12 hours