DrugDosingSide effects and complications
Calcium channel blockers
Diltiazem (Cardizem)Acute IV: 0.25 mg per kg over 2 minutes; then 0.35 mg per kg after 15 minutes if needed; then 10 mg per hour in drip if neededAcute: heart block, CHF, hypotension (∼3%)
Oral maintenance: 180 to 240 mg per dayLong-term: constipation
Verapamil (Calan)Acute IV: bolus of 5 to 10 mg over 2 minutes; may repeat 10 mg in 15 to 30 minutesAcute: heart block, CHF, hypotension (∼5% to 10%)
Oral maintenance: 240 to 320 mg per dayLong-term: constipation
Beta blockers
Propranolol (Inderal)Acute IV: 1 to 3 mg at 1 mg per minute; repeat in 2 minutes if needed.Acute: heart block, bronchospasm, CHF
Oral maintenance: 10 to 30 mg every 6 to 8 hoursLong-term: fatigue, depression
Esmolol (Brevibloc)Acute IV: 0.5 mg per kg over 1 minute; then 0.05 mg per kg per minute by IV drip for 4 minutesAcute: hypotension (20% to 50%), heart block, CHF
Digoxin (Lanoxin)Acute IV: 0.25 to 0.50 mg; then 0.25 mg every 4 to 6 hours to total of 1.0 mgHeart click, visual disturbances, delirium, hallucinations
Oral maintenance: 0.125 to 0.25 mg per day