Omeprazole (Prilosec)			Lansoprazole (Prevacid)		Rabeprazole (Aciphex)
Indication	Dosage	Duration of treatment	Dosage	Duration of treatment	Dosage	Duration of treatment
Short-term treatment of active duodenal ulcer	20 mg daily	4 weeks; another 4 weeks may be required	15 mg daily	4 weeks	20 mg daily	Up to 4 weeks; most will heal in this period; some patients may require additional therapy
Helicobacter pylori eradication for reduction of duodenal ulcer recurrence	Triple therapy: omeprazole, 20 mg, clarithromycin, 500 mg, and amoxicillin, 1,000 mg, each taken twice daily	Triple therapy: 10 days, plus 18 days of omeprazole therapy if an ulcer is present at initiation of treatment	Triple therapy: lansoprazole, 30 mg, amoxicillin, 1,000 mg, and clarithromycin, 500 mg, each taken twice daily	Triple therapy: 10 to 14 days	NA	NA
	Dual therapy: omeprazole, 40 mg daily, and clarithromycin, 500 mg, each three times daily	Dual therapy: 14 days, plus 14 days of omeprazole therapy at 20 mg daily if an ulcer is present at initiation of treatment	Dual therapy: lansoprazole 30 mg, and amoxicillin, 1,000 mg, each taken three times daily	Dual therapy: 14 days
Maintenance therapy for healed duodenal ulcer	NA	NA	15 mg daily	NA	NA	NA
Short-term treatment of gastric ulcer	40 mg daily	4 to 8 weeks	30 mg daily	Up to 8 weeks	NA	NA
Short-term symptomatic gastroesophageal reflux disease	20 mg daily	Up to 4 weeks	15 mg daily	8 weeks	NA	NA
Short-term erosive esophagitis	20 mg daily	4 to 8 weeks	30 mg daily	8 weeks; another 8 weeks of treatment may be required if not healed	20 mg daily	4 to 8 weeks; if not healed after 8 weeks, another 8 weeks of treatment may be considered
Maintenance therapy of erosive esophagitis	20 mg daily	NA	15 mg daily	NA	20 mg daily	NA
Pathologic hypersecretory conditions	Dosages vary; recommended starting dosage is 60 mg daily; dosages of 120 mg three times daily may be needed; dosages of more than 80 mg daily should be divided	Treatment for several years may be required	Dosages vary; usual starting dosage is 60 mg daily, up to 90 mg twice daily; dosages of more than 120 mg daily should be divided	Treatment for years may be required	Dosages vary; usual starting dosage is 60 mg daily, and dosages of 60 mg twice daily may be required	Treatment for several years may be required