Agents	Dosage	Use recommendation	Comments
Diuretics
Spironolactone44	100 mg per day	Luteal phase	Aldosterone antagonist
			Potassium-sparing diuretic
			Could improve physical and psychologic symptoms
Dopamine agonist
Bromocriptine4,20,45	Up to 2.5 mg three times per day	Days 10 through 26 of menstrual cycle	May relieve cyclic mastalgia; evaluate hepatic and renal functions before initiation
NSAIDs
Ibuprofen20	500 to 1,000 mg per day	Days 17 through 28 of menstrual cycle	Take with food May relieve mastalgia