Strategy	Dosage	Comments
Cognitive behavior therapy	Not applicable	Limited controlled evidence for efficacy
Buspirone (BuSpar)	15 to 60 mg daily	Evidence of efficacy is limited to favorable case reports; especially appropriate for patients with comorbid generalized anxiety disorder or mild depression because of efficacy in treating these comorbidities.
Benzodiazepines	See Table 1.	Growing controlled evidence of efficacy; especially appropriate for patients with another benzodiazepineresponsive condition such as generalized anxiety disorder; check for potential drug interactions, which vary by agent.
Beta blockers	Conventional dosages, which vary by agent	Experience is limited to favorable clinical experience, particularly with patients who have prominent autonomic symptoms.
Bupropion (Wellbutrin)	150 to 450 mg daily	Experience limited to favorable clinical experience; limited experience with use of this strategy in patients with depression; check for potential drug interactions.
TCAs	See Table 1; watch for potential drug interactions, which can increase serum TCA levels.	Evidence of efficacy is limited to small case-series; check for potential drug interactions.
Valproate (Depakote)	Conventional mood-stabilizing dosages	Evidence of efficacy is limited to case reports and small case-series; an obvious choice for patients with comorbid bipolar disorder.1