For mild to moderate migraine attacks or severe attacks that have been responsive in the past to similar agents, use the following options:
NSAIDs (oral)
Combination analgesics containing caffeine
Isometheptene combinations
For moderate to severe migraine or mild to moderate migraines that respond poorly to NSAIDs, use:
Migraine-specific drugs (i.e., triptans [naratriptan, rizatriptan, sumatriptan, zolmitriptan], DHE)
or
Combination drug therapy (e.g., aspirin plus acetaminophen* plus caffeine)
or
Other drugs such as ergotamine
For migraine accompanied by nausea or vomiting, use a non-oral route of administration.
For severe migraine that does not respond to other treatments, use a self-administered rescue medication.
Limit and carefully monitor the use of opiates and butalbital-containing analgesics.