| Acute pulmonary | Amphotericin B (Fungizone IV), 0.7 mg per kg per day* with corticosteroids† (prednisone [Deltasone], 60 mg daily for 2 weeks), then itraconazole (Sporanox), 200 mg once or twice daily* for 12 weeks | Symptoms less than four weeks: none |
| | Symptoms more than four weeks: itraconazole, 200 mg once or twice daily for six to 12 weeks |
| Chronic pulmonary | Amphotericin B,‡ then itraconazole for 12 to 24 months | Itraconazole for 12 to 24 months |
| Disseminated (in patients without AIDS) | Amphotericin B, 0.7 to 1.0 mg per kg per day,‡ then itraconazole for six to 18 months§ | Itraconazole for six to 18 months |
| Disseminated (in patients with AIDS) | Induction: amphotericin B,‡ then itraconazole, 200 mg twice daily, to complete a 12-week course | Induction: itraconazole, 200 mg three times daily for three days, then twice daily to complete a 12-week course |
| Maintenance: itraconazole for life | |
| | Maintenance: itraconazole for life |
| Granulomatous mediastinitis | Amphotericin B, then itraconazole for six to 12 months; also consider corticosteroids and/or surgical resection∥ | Itraconazole for six to 12 months |
| Pericarditis | Corticosteroids¶ and/or pericardial drainage | NSAIDs for two to 12 weeks |
| Rheumatologic | NSAIDs for two to 12 weeks | NSAIDs for two to 12 weeks |